Five-time champion Serena Williams reached her first Grand Slam quarter-final of 2014 at the US Open but Canadian poster girl Eugenie Bouchard, struggling in the heat and humidity, was knocked out.
World number one Williams, the two-time defending champion, eased past world number 50 Kaia Kanepi 6-3, 6-3 on Monday for a fourth win over the Estonian and goes on to face fellow 32-year-old Flavia Pennetta of Italy in a clash of the two oldest remaining players in the draw.
"It's my first quarter-final of the year at the majors -- at last I did it," said the American, who had fallen in the fourth round in Australia, the third round at Wimbledon and suffered a second round French Open exit.
"It was a tough match today. Kaia hits the ball very hard and moves the ball around really well. I wanted to stay relaxed and told myself that whatever happens, Serena, you're still in the doubles."
Seventh seeded Bouchard was at the centre of a medical drama on Louis Armstrong court when she had to have her blood pressure and temperature taken in her 7-6 (7/2), 6-4 defeat to Russian 17th seed Ekaterina Makarova.
Wimbledon runner-up Bouchard called the medical timeout at 2-3 down in the second set when she was obviously struggling in the 31-degree heat (87F) and humidity running at 60 percent.
She slipped 4-2 down, broke back for 4-3 but left-handed Makarova was too strong for the ailing Canadian as she booked a spot in the last-eight for the second successive year.
"I was feeling very light headed and dizzy on the court, just seeing things a little blurry. I just generally didn't feel good," said Bouchard whose defeat meant that for only the second time in the Open era there will be just one top-eight seed in the quarter-finals of a major.
"It developed as the match went on. I have had a few late, tough matches here, and I don't think I fully recovered from those."
Bouchard's defeat ended her run of having reached at least the semi-finals at all the majors this year and also means that for the first time since 1977, the four Grand Slam women's championship matches will have featured eight different players.
Makarova next faces former world number one Victoria Azarenka, the runner-up to Williams in 2012 and 2013, who came back from a set down to defeat 145th-ranked Serbian qualifier Aleksandra Krunic, 4-6, 6-4, 6-4.
Krunic, 21, who is studying for an economics degree when she is not playing tennis, stunned third seed and Wimbledon champion Petra Kvitova to reach her first major last-16.
- Azarenka survives scare-
And the slender 5ft 4in (1.63m) Serb almost added Azarenka to her list of victims when she recovered from a double-break down in the first set to take the opener in a wonderful display of uninhibited hitting.
But the bigger, stronger Azarenka eventually prevailed over an opponent attempting to be the first qualifier to make the last-eight in New York in 33 years.
"Aleksandra played amazing, she has a great future in the sport. I tried to be positive and I turned the match around," said Azarenka, down at 17 in the world after a season in which she has struggled with a left foot injury.
Italian 11th seed Pennetta reached her fifth quarter-final in New York with a 7-5, 6-2 victory over Australian 29th seed Casey Dellacqua.
Pennetta made the semi-finals in 2013, where she was defeated by Azarenka, and despite having a 5-0 losing record against Williams, she refuses to believe that the outcome of Wednesday's quarter-final is a foregone conclusion.
"Of course she's better than me, but I still believe I can beat her. If she doesn't have a good day I can do that," said Pennetta of an opponent who has dropped just 17 games in four rounds so far.
The quarter-finals in the bottom half of the draw take place on Tuesday and feature 17-year-old Belinda Bencic up against China's Peng Shuai while former world number one and 2009 runner-up Caroline Wozniacki faces Italy's Sara Errani.
Source: AFP