Despite their big size, elephants rarely get cancer, and scientists said Thursday they have discovered the secret to the creatures' special protection. It's in the genes.
Elephants have 38 additional modified copies of a gene that encodes p53, a compound that suppresses tumor formation.
Humans, on the other hand, have only two, according to the study in the Journal of the American Medical Association (JAMA).
This means that as elephants evolved, their bodies made many extra copies of a gene that prevents tumors from forming.
Elephants have been considered an enigma for years because they have far more cells than people, which would presumably place them at higher risk of cancer over their lifespans which can last 50-70 years.
And yet, the analysis of a large database of elephant deaths showed that less than five percent of elephants die of cancer, compared to 11 to 25 percent in people.
"By all logical reasoning, elephants should be developing a tremendous amount of cancer, and in fact, should be extinct by now due to such a high risk for cancer," said co-senior author Joshua Schiffman, pediatric oncologist at Huntsman Cancer Institute, University of Utah School of Medicine.
"We think that making more p53 is nature's way of keeping this species alive."
Elephants also come naturally equipped with a more aggressive internal mechanism for killing damaged cells that are at risk for becoming cancerous, researchers said.
"In isolated elephant cells, this activity is doubled compared to healthy human cells," said the study, which was co-authored by experts from Arizona State University and the Ringling Bros. Center for Elephant Conservation.
Researchers hope that their findings could one day lead to new cancer-fighting therapies in people.
But that day could be far off, according to Mel Greaves, director of the Centre for Evolution and Cancer at The Institute of Cancer Research, London.
"The new research provides a plausible answer to one of the most celebrated riddles in evolutionary biology –- why some big animals with lots of cells still manage to have quite low rates of cancer," said Greaves, who was not involved in the study.
"It is not immediately clear what lessons there are from this elephant tale for risk of cancer in humans. The main impact of this remarkable story is to bring into focus the question of why we are so uniquely predisposed to cancer for our size and lifespan –- and what we can do to change this."
GMT 12:33 2018 Sunday ,21 January
Hot air? Study finds bikram no healthier than other yogaGMT 06:23 2018 Saturday ,13 January
'How much do you earn?' Germany takes on gender pay gapGMT 10:36 2017 Tuesday ,24 October
So how do mega-storms get named, anyhow?GMT 10:33 2017 Tuesday ,24 October
What is storm surge and why is it so dangerous?GMT 11:17 2017 Tuesday ,14 March
Will March snow cherry blossoms?GMT 12:05 2017 Tuesday ,07 March
Is Arctic sea ice doomed to disappear?GMT 12:32 2017 Monday ,20 February
Why online retail growth in the UAE is different than in the rest of the worldGMT 08:16 2017 Wednesday ,01 February
One income for all: far-fetched, or future fact with technology-driven changes?Maintained and developed by Arabs Today Group SAL.
All rights reserved to Arab Today Media Group 2021 ©
Maintained and developed by Arabs Today Group SAL.
All rights reserved to Arab Today Media Group 2021 ©
Send your comments
Your comment as a visitor